The CHEST 2010 annual meeting offers clinical instruction in pulmonary, critical care, and sleep medicine. These features include research presented on diabetes drugs fighting lung cancer progression, how diet impacts COPD, and the role of electronic media in daytime function and sleep disorders.
The Particulars: Previous research has suggested an association between metformin and/or thiazolidinedione (TZD) use and the risk of developing lung cancer. A study was conducted to determine the influence of metformin and TZDs on lung cancer presentation and course.
Data Breakdown: Researchers reviewed the medical records of 157 patients with diabetes who had a history of lung cancer. Patients who were exposed to either metformin or TZDs were significantly less likely to have metastatic disease (20.0% vs 42.4%) or a small cell or squamous cell carcinoma. They also demonstrated improved survival (hazard ratio, 0.56). There were no significant differences between the age, sex, and smoking histories of the group exposed to metformin or TZDs prior to their lung cancer diagnosis.
Take Home Pearl: Use of metformin and/or TZDs appears to lower risks of advanced lung cancer. These medications also correlated with an improved survival rate among patients with diabetes who developed concomitant lung cancer.
Diet Impacts Lung Function in COPD [back to top]
The Particulars: The role antioxidants play in lung function in patients with COPD is unclear. A study was conducted to assess the role of antioxidants with regard to lung function in men and women with COPD.
Data Breakdown: Researchers analyzed questionnaires from COPD patients that assessed intake of selenium and vitamins A, C, D, and E. The following percentages of participants had deficiencies: 25% for selenium; 45% for vitamin C; 90% for vitamin E; 55% for vitamin A; and 70% for vitamin D. Decreased lung function was observed in all COPD patients with diets deficient in selenium. Of those deficient in vitamins A, C, and D, lung function was only worse in men.
Take Home Pearls: A poor diet—one low in dietary intake of certain antioxidants—appears to worsen lung function in patients with COPD. Poor diet may also increase the likelihood of decreased lung function, especially men.
Electronic Media, Daytime Function, & Mood in Teens [back to top]
The Particulars: The prevalence of insomnia and other sleep disorders is cause for concern among teenagers, and many are increasing their use of cell phones or computers. A study was performed to examine the effects of sleep time-related information and communication technology on sleep patterns and daytime functioning in teens.
Data Breakdown: Investigators analyzed responses from 40 students who completed a modified version of the Children’s Sleep Habits Questionnaire. More than 77% of responders had persistent problems getting to sleep. The average number of times a student was awakened by communication technology was once per night. The average number of texts or emails sent per night was 33.5.
Take Home Pearls: Mood and cognitive problems during the daytime appear to be apparent in most teenagers who use electronic media before bedtime. Teens who engage in pre-bedtime use of technology have higher rates of daytime problems, including mental disorders and learning difficulties.
For more information on these studies and others that were presented at CHEST 2010, go towww.accpmeeting.org.