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Connection between bone remodeling and inflammatory markers in obstructive sleep apnea in relation to disease severity

Connection between bone remodeling and inflammatory markers in obstructive sleep apnea in relation to disease severity
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Bromińska B, Cyrańska-Chyrek E, Kuźnar-Kamińska B, Kostrzewska M, Winiarska H, Sawicka-Gutaj N, Zybek-Kocik A, Hernik A, Wrotkowska E, Krasiński Z, Ruchała M, Batura-Gabryel H,


Bromińska B, Cyrańska-Chyrek E, Kuźnar-Kamińska B, Kostrzewska M, Winiarska H, Sawicka-Gutaj N, Zybek-Kocik A, Hernik A, Wrotkowska E, Krasiński Z, Ruchała M, Batura-Gabryel H, (click to view)

Bromińska B, Cyrańska-Chyrek E, Kuźnar-Kamińska B, Kostrzewska M, Winiarska H, Sawicka-Gutaj N, Zybek-Kocik A, Hernik A, Wrotkowska E, Krasiński Z, Ruchała M, Batura-Gabryel H,

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Polish archives of internal medicine 2017 11 07() doi 10.20452/pamw.4143
Abstract

INTRODUCTION    There is growing evidence that obstructive sleep apnea (OSA) influences both bone metabolism and structure. Chitinase-3-like protein 1 (YKL-40) is a novel inflammatory and remodeling marker, which was shown to increase in OSA. YKL-40 can probably alter the bone turnover.   OBJECTIVES    Assessment of a possible interplay between YKL-40 and bone turnover markers in patients with different stages of OSA. Evaluation of the relation among bone mass, OSA severity, and YKL-40 level. PATIENTS AND METHODS    The study is based on 72 male OSA patients divided into three groups according to disease severity using apnea-hypopnea index (AHI): OSA 1 n = 18 (5 ≤ AHI < 15), OSA 2 n = 25 (15 ≤ AHI < 30), OSA 3 n = 29 (AHI ≥ 30). All subjects have undergone polysomnography and densitometry. Fasting blood samples were collected for YKL-40, C-terminal telopeptide of type-1 collagen (CTX), Procollagen type 1 N-terminal propeptide (P1NP) and other markers.  RESULTS    P1NP differed between OSA 1 and OSA 2; OSA 1 and OSA 3 (P = 0.02). OSA 2 had higher CTX than OSA 1 (borderline statistical significance P = 0.05). Simple linear regression analysis showed that YKL-40 serum levels were significantly associated with CTX (P < 0.0001, β = 0.9871) and P1NP (P <0.0001, β = 0.9780) levels.  CONCLUSIONS    Our study might suggest that YKL-40 is associated with bone turnover in OSA. We may assume that it influences both bone formation and destruction; thus, OSA could be characterized by preserve BMD.

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