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Correlation between serum interleukin-6 level and type 1 diabetes mellitus: A systematic review and meta-analysis.

Correlation between serum interleukin-6 level and type 1 diabetes mellitus: A systematic review and meta-analysis.
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Chen YL, Qiao YC, Pan YH, Xu Y, Huang YC, Wang YH, Geng LJ, Zhao HL, Zhang XX,


Chen YL, Qiao YC, Pan YH, Xu Y, Huang YC, Wang YH, Geng LJ, Zhao HL, Zhang XX, (click to view)

Chen YL, Qiao YC, Pan YH, Xu Y, Huang YC, Wang YH, Geng LJ, Zhao HL, Zhang XX,

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Cytokine 2017 03 07() pii S1043-4666(17)30002-9
Abstract
OBJECTIVE
This report aimed to explore the association between the change of circulating interleukin-6 (IL-6) in patients and the development of type 1 diabetes mellitus (T1DM).

METHODS
Four databases (PubMed, CNKI, WanFang and Civip) were used to search and list all clinical case-control studies about serum IL-6 level in T1DM patients between Jan 1, 2000 and Aug 31, 2016.

RESULTS
A total of 20 case-control studies with 1238 T1DM patients and 742 healthy controls were included in this study. Compared to healthy controls, the serum content of IL-6 in patients with T1DM was significantly greater (overall: SMD, 1.49; 95% CI, 1.04 to 1.93; p<0.001), and notably increased in all subgroup with different age, ethnic and disease duration (all p<0.001). Furthermore, the analysis in subgroup exhibited that serum levels of IL-6 in the age greater than 20-year old (SMD, 1.64; 95% CI, 0.57-2.71; p<0.001), the diseased duration among 0-10years (SMD, 2.43; 95% CI, 1.42-3.44; p<0.001) and the sorted American group (SMD, 1.68; 95% CI, 0.85-2.51; p<0.001) were higher than those in control groups. CONCLUSIONS
Patients with T1DM were found to be linked to elevated level of serum IL-6, which the age, ethnic and disease durations in T1DM patients had no effect on the serum IL-6 levels for promoting diabetes mellitus.

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