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Correlation of X-ray diffraction signatures of breast tissue and their histopathological classification.

Correlation of X-ray diffraction signatures of breast tissue and their histopathological classification.
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Moss RM, Amin AS, Crews C, Purdie CA, Jordan LB, Iacoviello F, Evans A, Speller RD, Vinnicombe SJ,


Moss RM, Amin AS, Crews C, Purdie CA, Jordan LB, Iacoviello F, Evans A, Speller RD, Vinnicombe SJ, (click to view)

Moss RM, Amin AS, Crews C, Purdie CA, Jordan LB, Iacoviello F, Evans A, Speller RD, Vinnicombe SJ,

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Scientific reports 2017 10 117(1) 12998 doi 10.1038/s41598-017-13399-9
Abstract

This pilot study examines the correlation of X-ray diffraction (XRD) measurements with the histopathological analysis of breast tissue. Eight breast cancer samples were investigated. Each sample contained a mixture of normal and cancerous tissues. In total, 522 separate XRD measurements were made at different locations across the samples (8 in total). The resulting XRD spectra were subjected to principal component analysis (PCA) in order to determine if there were any distinguishing features that could be used to identify different tissue components. 99.0% of the variation between the spectra were described by the first two principal components (PC). Comparing the location of points in PC space with the classification determined by histopathology indicated correlation between the shape/magnitude of the XRD spectra and the tissue type. These results are encouraging and suggest that XRD could be used for the intraoperative or postoperative classification of bulk tissue samples.

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