WEDNESDAY, Dec. 9, 2020 (HealthDay News) — People with a “significant history” of allergic reactions should not receive the new Pfizer-BioNTech COVID-19 vaccine, U.K. regulators said Tuesday.

The advice was issued after two people suffered adverse reactions on the first day of the U.K. mass vaccination program, the Associated Press reported. The regulators said they are investigating the two cases. “As is common with new vaccines the [Medical and Healthcare Products Regulatory Agency (MHRA)] have advised on a precautionary basis that people with a significant history of allergic reactions do not receive this vaccination after two people with a history of significant allergic reactions responded adversely yesterday,” Stephen Powis, national medical director of the National Health Service, said in a statement, the AP reported. “Both are recovering well,” he added.

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“We know from the very extensive clinical trials that this wasn’t a feature,” June Raine, head of the MHRA, told a Parliamentary committee, the AP reported. “But If we need to strengthen our advice, now that we have had this experience with the vulnerable populations, the groups who have been selected as a priority, we get that advice to the field immediately.”

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