Advertisement

 

 

Crotamine induces browning of adipose tissue and increases energy expenditure in mice.

Crotamine induces browning of adipose tissue and increases energy expenditure in mice.
Author Information (click to view)

Marinovic MP, Campeiro JD, Lima SC, Rocha AL, Nering MB, Oliveira EB, Mori MA, Hayashi MAF,


Marinovic MP, Campeiro JD, Lima SC, Rocha AL, Nering MB, Oliveira EB, Mori MA, Hayashi MAF, (click to view)

Marinovic MP, Campeiro JD, Lima SC, Rocha AL, Nering MB, Oliveira EB, Mori MA, Hayashi MAF,

Advertisement

Scientific reports 2018 03 228(1) 5057 doi 10.1038/s41598-018-22988-1

Abstract

Crotamine, originally isolated from rattlesnake venom, has been extensively studied due to its pleiotropic biological properties, and special attention has been paid to its antitumor activity. However, long-term treatment with crotamine was accompanied by a reduction in animal body weight gain and by increases in glucose tolerance. As cancer is commonly associated with cachexia, to preclude the possible cancer cachexia-like effect of crotamine, herein this polypeptide was administered in healthy wild-type C57/BL6 mice by the oral route daily, for 21 days. Reduced body weight gain, in addition to decreased white adipose tissue (WAT) and increased brown adipose tissue (BAT) mass were observed in healthy animals in the absence of tumor. In addition, we observed improved glucose tolerance and increased insulin sensitivity, accompanied by a reduction of plasma lipid levels and decreased levels of biomarkers of liver damage and kidney disfunctions. Importantly, long-term treatment with crotamine increased the basal metabolic rate in vivo, which was consistent with the increased expression of thermogenic markers in BAT and WAT. Interestingly, cultured brown adipocyte cells induced to differentiation in the presence of crotamine also showed increases in some of these markers and in lipid droplets number and size, indicating increased brown adipocyte maturation.

Submit a Comment

Your email address will not be published. Required fields are marked *

5 × 4 =

[ HIDE/SHOW ]