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Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release.

Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release.
Author Information (click to view)

Li X, Zhao Y, Wang K, Wang L, Yang X, Zhu S,


Li X, Zhao Y, Wang K, Wang L, Yang X, Zhu S, (click to view)

Li X, Zhao Y, Wang K, Wang L, Yang X, Zhu S,

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PloS one 2017 12 1512(12) e0189778 doi 10.1371/journal.pone.0189778
Abstract

To improve the efficacy of anti-inflammatory factors in patients who undergo cataract surgery, poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) hydrogels containing β-cyclodextrin (β-CD) (pHEMA/MMA/β-CD) were designed and prepared as intraocular lens (IOLs) biomaterials that could be loaded with and achieve the sustained release of dexamethasone. A series of pHEMA/MMA/β-CD copolymers containing different ratios of β-CD (range, 2.77 to 10.24 wt.%) were obtained using thermal polymerization. The polymers had high transmittance at visible wavelengths and good biocompatibility with mouse connective tissue fibroblasts. Drug loading and release studies demonstrated that introducing β-CD into hydrogels increased loading efficiency and achieved the sustained release of the drug. Administering β-CD via hydrogels increased the equilibrium swelling ratio, elastic modulus and tensile strength. In addition, β-CD increased the hydrophilicity of the hydrogels, resulting in a lower water contact angle and higher cellular adhesion to the hydrogels. In summary, pHEMA/MMA/β-CD hydrogels show great potential as IOL biomaterials that are capable of maintaining the sustained release of anti-inflammatory drugs after cataract surgery.

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