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Cytomegalovirus (CMV) kinetics following primary infection in healthy women.

Cytomegalovirus (CMV) kinetics following primary infection in healthy women.
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Forman MS, Vaidya D D, Bolorunduro O, Diener-West M, Pass RF, Arav-Boger R,


Forman MS, Vaidya D D, Bolorunduro O, Diener-West M, Pass RF, Arav-Boger R, (click to view)

Forman MS, Vaidya D D, Bolorunduro O, Diener-West M, Pass RF, Arav-Boger R,

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The Journal of infectious diseases 2017 04 18() doi 10.1093/infdis/jix188

Abstract

The kinetics of CMV DNA in infected asymptomatic hosts are largely unknown. We measured viral load (VL) in 124 fluid samples (oral, urine, vaginal, blood) collected from 21 women who acquired CMV. A quantitative real-time PCR of US17, which correlated with clinical assays, was used. VL decreased following primary infection in all fluids. The geometric mean VL of vaginal fluid was significantly higher than that of other sources: oral (3.89 95% CI [1.43 – 10.57]), urine (6.36 95% CI [2.48 – 16.32]) and whole blood (11.88 95% CI [4.12 – 34.20]). Vaginal CMV shedding may provide a route for sexual and possibly perinatal transmission.

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