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The following is a summary of “Incidence and Prevalence of Glaucoma, Corticosteroid Response, and Ocular Hypertension in Uveitis and its Anatomical Subtypes,” published in the June 2025 issue of American Journal of Ophthalmology by Marshall et al. 

Researchers conducted a retrospective study to evaluate the cumulative and annual prevalence and incidence of uveitic glaucoma within the TriNetX United States (US) Collaborative Network database.  

They used the TriNetX US database to identify a uveitic glaucoma cohort, including patients with ICD-10 codes for uveitis and either glaucoma, ocular hypertension, or corticosteroid response diagnosed on the same day or after uveitis onset. Demographic data were collected, and cumulative as well as yearly incidence and prevalence of uveitic glaucoma from 2013 to 2022 were calculated. A sub-analysis of uveitis anatomic location was also performed.  

The results showed that 30,681 patients with uveitic glaucoma were identified, with an average age of 67 years (SD=19, 95% CI 66.8-67.2 years); 55.0% (n=16,875, 95% CI 54.4-55.9%) were female, and 50.7% (n=15,555, 95% CI 50.1-51.3%) were Caucasian. Among the uveitis population, 15.5% developed glaucoma over 10 years (n=30,681, 95% CI 15.3-15.6%). The cumulative incidence was 5 per 10,00,000, and prevalence was 27 per 1,00,000 between 2013 and 2022, both declining during the study period. Patients with combined anterior and intermediate uveitis had the highest glaucoma rate (n=529; 20.3%, 95% CI 18.8-21.9%), followed by anterior (n=20,849; 16.4%, 95% CI 16.2-16.7%), panuveitis (n=48; 11.6%, 95% CI 8.5-14.7%), endophthalmitis (n=273; 11.3%, 95% CI 10.9-11.7%), intermediate (n=173; 10.0%, 95% CI 8.6-11.5%), and posterior uveitis (n=1,579; 8.2%, 95% CI 7.8-8.6%). The highest rates of ocular hypertension (n=465; 17.9%, 95% CI 16.4-19.3%) and corticosteroid response (n=279; 10.7%, 95% CI 9.5-11.9%) were observed in the anterior and intermediate uveitis groups.  

Investigators concluded that the incidence and prevalence of uveitic glaucoma have declined since 2013, patients having both anterior and intermediate uveitis showing the highest relative glaucoma rates among uveitis subtypes. 

Source: ajo.com/article/S0002-9394(25)00285-5/abstract