Deep grey matter injury in multiple sclerosis: A NAIMS consensus statement.

Mar 25, 2021

Contributor: Daniel Ontaneda,Praneeta C Raza,Kedar R Mahajan,Douglas L Arnold,Michael G Dwyer,Susan A Gauthier,Douglas N Greve,Daniel M Harrison,Roland G Henry,David K B Li,Caterina Mainero,Wayne Moore,Sridar Narayanan,Jiwon Oh,Raihaan Patel,Daniel Pelletier,Alexander Rauscher,William D Rooney,Nancy L Sicotte,Roger Tam,Daniel S Reich,Christina J Azevedo,

Deep grey matter injury in multiple sclerosis: A NAIMS consensus statement.

Although multiple sclerosis (MS) has traditionally been considered a white matter disease, extensive research documents the presence and importance of gray matter injury including cortical and deep regions. The deep gray matter (DGM) exhibits a broad range of pathology and is uniquely suited to study the mechanisms and clinical relevance of tissue injury in MS using magnetic resonance techniques. DGM injury has been associated with clinical and cognitive disability. Recently, MRI characterization of DGM properties, such as thalamic volume, have been tested as potential clinical trial endpoints associated with neurodegenerative aspects of MS. Given this emerging area of interest and its potential clinical trial relevance, the North American Imaging in MS (NAIMS) Cooperative held a workshop and reached consensus on imaging topics related to the DGM. Herein, we review current knowledge regarding DGM injury in MS from an imaging perspective, including insights from histopathology, image acquisition and post-processing for DGM. We discuss the clinical relevance of DGM injury and specific regions of interest within the DGM. We highlight unanswered questions and propose future directions, with the aim of focusing research priorities towards better methods, analysis, and interpretation of results.
© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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About The Expert

Daniel Ontaneda

Cleveland Clinic Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Ohio, USA.

Praneeta C Raza

Cleveland Clinic Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Ohio, USA.

Kedar R Mahajan

Cleveland Clinic Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Ohio, USA.

Douglas L Arnold

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada.

Michael G Dwyer

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, The State University of New York, Buffalo, NY, USA.

Susan A Gauthier

Department of Neurology, Weill Cornell Medicine, New York, NY, USA.

Douglas N Greve

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

Harvard Medical School, Boston, MA, USA.

Daniel M Harrison

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.

Roland G Henry

Departments of Neurology, Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.

The UC San Francisco and Berkeley Bioengineering Graduate Group, University of California San Francisco, San Francisco, CA, USA.

David K B Li

Departments of Radiology and Medicine (Neurology), University of British Columbia, Canada, Vancouver, BC, Canada.

Caterina Mainero

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

Harvard Medical School, Boston, MA, USA.

Wayne Moore

Department of Pathology and Laboratory Medicine, and International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.

Sridar Narayanan

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada.

Jiwon Oh

Division of Neurology, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada.

Raihaan Patel

Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Canada.

Department of Biological and Biomedical Engineering, McGill University, Montreal, Canada.

Daniel Pelletier

Department of Neurology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

Alexander Rauscher

Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.

William D Rooney

Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR 97239, USA.

Nancy L Sicotte

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Roger Tam

Departments of Radiology and Medicine (Neurology), University of British Columbia, Canada, Vancouver, BC, Canada.

Biomedical Engineering, University of British Columbia, Canada.

Daniel S Reich

Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.

Christina J Azevedo

Department of Neurology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

References

PubMed