For adults with moderate-to severe AD, depressive symptoms are common, according to a study published in Acta Dermato -Venereologica. Lina U. Ivert, MD, and colleagues conducted a prospective, real-world, clinical cohort study that analyzed baseline, 6-month, and 12-month data from 120 patients with AD undergoing systemic treatment. At baseline, more than one-half of patients with moderate-to-severe AD exhibited depressive symptoms. A total of 24% patients reported moderate-to-severe depression, and 3% had pronounced suicidal ideation. Systemic treatment of AD greatly reduced both AD symptoms and depression at 6 months, which were sustained at 12 months.