Clinical research is critical for determining the effectiveness of health-care treatments. Vaccine clinical trials are designed to assess the efficacy and safety of vaccines for disease prevention. Infectious illnesses such as malaria, TB, HIV/AIDS, and Ebola virus disease are prevalent throughout Africa. In this paper, researchers provide the results of a database monitoring analysis of vaccine-related clinical trials done in Africa. One goal is to address and publicize vaccination clinical studies being done in Africa. On 22 July 2018, data were collected from the WHO International Clinical They discovered that 61% of the 377 clinical studies were registered prospectively, whereas 35% were registered retrospectively. Approximately 72% of the trials were single-country studies, with the majority of trials being single-center studies within the nation. The proportion of trials involving several African nations was 11%, whereas the proportion of trials involving countries outside Africa was 16%. Malaria, HIV/AIDS, TB, and Ebola virus illness were the most researched diseases. The majority of vaccination studies were done on adults. The trials spanned from phase I through phase IV, with the majority of them in phases I and III.

The conduct of vaccination clinical trials in Africa aims to alleviate the continent’s disease outbreaks. More government funding in vaccine development in Africa is required. Furthermore, African country partnerships are required in attempts to identify African solutions to the continent’s existing infectious disease challenges.