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Detection and genotyping of human papillomavirus (HPV) in HIV-infected women and its relationship with HPV/HIV co-infection.

Detection and genotyping of human papillomavirus (HPV) in HIV-infected women and its relationship with HPV/HIV co-infection.
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Badial RM, Dias MC, Stuqui B, Melli PPDS, Quintana SM, Bonfim CMD, Cordeiro JA, Rabachini T, Calmon MF, Provazzi PJS, Rahal P,


Badial RM, Dias MC, Stuqui B, Melli PPDS, Quintana SM, Bonfim CMD, Cordeiro JA, Rabachini T, Calmon MF, Provazzi PJS, Rahal P, (click to view)

Badial RM, Dias MC, Stuqui B, Melli PPDS, Quintana SM, Bonfim CMD, Cordeiro JA, Rabachini T, Calmon MF, Provazzi PJS, Rahal P,

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Medicine 97(14) e9545 doi 10.1097/MD.0000000000009545

Abstract

HPV have been identified as high-risk and low-risk, depending on their association with the development of cancer. HPV infections can be facilitated by co-infection with HIV. Here, we investigated HPV prevalence and genotypes and the risk factors affecting HPV/HIV co-infection. Forty HIV-positive patients had 80 cervical swab samples collected in 2 consecutive years. Polymerase chain reaction and DNA direct sequencing were used to perform HPV genotyping. Statistical analyses were performed regarding risk factors for HPV/HIV co-infection and the occurrence of cervical lesions. HPV DNA was detected in 59 samples (73.75%), and high-risk HPVs were predominant (59.3%). The most prevalent type was HPV56 (17%), followed by HPV16 (15.3%). Patient age did not affect the risk of cervical cancer (P = .84) or HPV prevalence in different years (P = .25/P = .63). CD4 count also did not affect the risk for cervical lesions in the tested samples (P = .15/P = .28). Although the HIV viral load was not correlated with an increase in cervical lesion detection in the first group of analyzed samples (P = .12), it did affect cervical cancer risk in the group of samples analyzed in the following year (P = .045). HIV-infected patients presented a high prevalence of HPV co-infection, and HPV16 and HPV56 were the most prevalent genotypes. Considering this, it is possible that immunodeficiency can contribute to increased susceptibility to HPV56 infection in HIV-infected patients. The association between HIV viral load and the lesions also confirmed the importance of monitoring HIV/HPV co-infected patients with high HIV viral loads.

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