This study’s objective was to identify factors affecting and outcome induced safe second-trimester medical abortion in Jimma University medical center, Southwest Ethiopia. 

All (201) eligible study subjects included were those who came for secure medical abortion service during the data collection period. Data collected using pretested structured questionnaires through exit-interviewing and some clinical data abstracted from their chart. The data was entered into EpData version 3.1 then exported to SPSS version 21.0 for analysis. Researchers obtained ethical clearance, and researchers kept confidentiality using codes and the patient’s chart number. 

In this study, the response rate was 98.1%. Previous experience of abortion, gestational age, parity, cervical status, overall waiting time for more than two weeks, overall waiting time for two weeks were independent predictors for the outcome of safe second-trimester medical abortion. This finding implied that the proportion of complete abortion without any complication overweighs incomplete abortions with one or more difficulty through induced secure second-trimester medical abortion method. The outcome is strongly determined by gestational age, cervical status, previous experience of abortion, parity, moderate anemia, and overall waiting time. Induced second-trimester medical abortion is already known as an effective and safe method. However, much should be done to reduce the proportion of incomplete abortions by minimizing overall waiting time through intervening at low gestational age.