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Development of an RNA aptamer that acquires binding capacity against HIV-1 Tat protein via G-quadruplex formation in response to potassium ions.

Development of an RNA aptamer that acquires binding capacity against HIV-1 Tat protein via G-quadruplex formation in response to potassium ions.
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Yamaoki Y, Nagata T, Mashima T, Katahira M,


Yamaoki Y, Nagata T, Mashima T, Katahira M, (click to view)

Yamaoki Y, Nagata T, Mashima T, Katahira M,

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Chemical communications (Cambridge, England) 2017 06 1653(52) 7056-7059 doi 10.1039/c7cc03312e

Abstract

For the development of K(+)-responsive RNA aptamers, we proposed a new general strategy that makes use of a G-quadruplex formation in response to K(+). This is the first report of developing an RNA aptamer that demonstrates ON/OFF switching of its target-binding activity by sensing the addition/removal of K(+).

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