The study was done to evaluate the association of diabetes duration and recent weight change with subsequent risk of pancreatic cancer in the general population.
Hazard ratios for subsequent development of pancreatic cancer.
112 818 women data results and 46 207 men were included in the analysis out of which 1116 incident cases of pancreatic cancers were identified. People with recent-onset diabetes had an age-adjusted HR for pancreatic cancer of 2.97 and those with long-standing diabetes had an age-adjusted HR of 2.16. Compared with those with no weight loss, participants who reported a 1- to 4-lb weight loss had an age-adjusted HR for pancreatic cancer of 1.25, those with a 5- to 8-lb weight loss had an age-adjusted HR of 1.33, and those with more than an 8-lb weight loss had an age-adjusted HR of 1.92. Recent-onset diabetes having patients faced weight loss of 1 to 8 lb. Incidence rates were even higher among participants with recent-onset diabetes and weight loss with a body mass index of less than 25 before weight loss or whose weight loss was not intentional judging from increased physical activity or healthier dietary choices.
This study concluded that recent-onset diabetes accompanied by weight loss is associated with a substantially increased risk for developing pancreatic cancer.
Reference: https://jamanetwork.com/journals/jamaoncology/article-abstract/2769304
