The following is a summary of “Diagnostic Utility of Mucosal Biopsies Taken During Colonoscopy-Guided Colonic Manometry Catheter Placement,” published in the November 2023 issue of Pediatrics by Armstrong, et al.

For a study, researchers sought to assess the diagnostic utility of mucosal biopsies taken during colonoscopy-guided colonic manometry catheter placement. The specific objectives were to determine mucosal biopsies’ frequency and histopathology results during these procedures and to evaluate any associations between histological or gross findings and manometry results.

A retrospective chart review was conducted on children who underwent colonic manometry between 2008 and 2020 at a quaternary children’s hospital. Patient demographics, biopsy locations, histopathology results, gross endoscopy findings, and manometry results were captured. The chi-squared test and Fisher exact test, when appropriate, were used for categorical associations.

The study included 148 patients, of which 80% had colonic biopsies and 43% had ileal biopsies. Colonic histology findings included lymphonodular hyperplasia (34%), normal (27%), chronic inflammation (24%), melanosis coli (21%), colonic eosinophilia (10%), and acute inflammation (8%). Ileal histology findings included increased Peyer patches (44%), normal (44%), acute inflammation (11%), chronic inflammation (3%), eosinophilia (5%), and eosinophilic ileitis (3%). Acute and chronic inflammation were mostly graded as mild. No statistically significant associations were found between histology, gross endoscopy, or manometry findings.

Colonic biopsies were commonly obtained during colonic manometry evaluation, with ileal biopsies less frequent. While histopathology findings were frequent, most did not impact clinical care. Moreover, no associations were observed between abnormal histopathology or abnormal gross endoscopy findings and colonic manometry results.

Source: journals.lww.com/jpgn/abstract/2023/11000/diagnostic_utility_of_mucosal_biopsies_taken.16.aspx