This study states that Serological assays have the potential to play an important role in the surveillance of COVID-19. The results of early seroprevalence studies have indicated that during the first wave of the COVID-19 pandemic, up to 10% of the population of Wuhan, China may have been infected, and up to 33% in cities of other countries have experienced large outbreaks.9, 10 Serology can also be used for the diagnosis of acute infection and can form an important tool in containment strategies by identifying and linking clusters of infection.11 If a serological immune correlate of protection can be found, these assays may also form part of exit strategies from control measures.12
While serological assays have been reported to have high sensitivity and specificity for SARS-CoV-2 infection, this reflects diagnostic performance during convalescence.13 Understanding antibody kinetics during early SARS-CoV-2 infection is critical for assessing the accuracy of diagnostic serological results and for interpreting the results of seroprevalence studies. To address this issue, we conducted a systematic review and meta-analysis to evaluate the diagnostic performance of serological assays in early COVID-19.
Reference link- https://onlinelibrary.wiley.com/doi/10.1111/irv.12841
