For a review, researchers aimed to address the general and most recent findings of the role of nutrition, lifestyle, supplements, and some prescription heart-healthy drugs on prostate cancer prevention. With the inclusion of more prospective observational and randomized controlled trial data, the notion of enhancing heart health to avoid aggressive prostate cancer had been further reinforced. A healthy heart is a healthy prostate, but a sick heart is a sick prostate. The primary objective of lowering the risk of all-cause and cardiovascular disease (CVD) morbidity and death also allowed for the best possible prostate cancer prevention. Obesity in children and adults, as well as current multidisciplinary studies, had only emphasized the link between heart and prostate health. Greater dietary adherence to a range of healthful foods was linked to a lower risk of CVD and potentially aggressive cancer risk reduction. Prevention of prostate cancer by dietary supplements urged a “first do no harm” or “less is more” strategy until future research reversed the troubling trend that increasing supplementing had resulted in either no effect or an increased risk of prostate cancer. Supplements designed to decrease the negative effects of various cancer therapies appeared to have more promising results. Pharmaceuticals that promoted heart health, such as statins, aspirin, metformin (S.A.M.), and specialized beta-blocker medications, were generally generic or low-cost and continued to pique the interest of researchers. In medical education, a watershed moment arrived in which the previous vision of a diverse number of trees apparently separated by wide distances now appears to reside inside the same forest.