Dietary and clinical features, serum adipokine concentrations, and metabolites differ according to whether gout is early- or late-onset, according to a study published in Metabolites. The mech- anisms of gout may differ between those with either type and require different treatment ap- proaches. Researchers aimed to identify differ- ences in clinical and dietary characteristics, se- rum adipokine levels, and metabolomic profiles between early- and late-onset gout. Eighty-three men with gout were divided into an early-onset group (n = 38, aged younger than 40) and a late-onset group (n = 45, aged 40 and older). The researchers obtained dietary and clinical infor- mation at baseline. Serum adipokines, including adiponectin, resistin, leptin, and plasminogen activator inhibitor-1 (PAI-1), were quantified by a Luminex multiplex immunoassay. Metab- olite expression levels in plasma were measured in 22 representative samples using metabolomics analysis based on ultra-performance liquid chro- matography coupled with quadrupole time-of- flight mass spectrometry. Average BMI, rate of consumption of sugar-sweetened beverages, and serum uric acid levels were significantly higher in the early-onset group, as was the PAI-I concen- tration (105.01 ± 42.45 ng/mL vs 83.76 ± 31.16 ng/mL). Changes in metabolite levels mostly in- volved those related to lipid metabolism.
