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Disseminated histoplasmosis presenting as multiple oral ulcers.

Disseminated histoplasmosis presenting as multiple oral ulcers.
Author Information (click to view)

Hendren N, Yek C, Mull J, Cutrell JB,


Hendren N, Yek C, Mull J, Cutrell JB, (click to view)

Hendren N, Yek C, Mull J, Cutrell JB,

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BMJ case reports 2017 07 142017() pii 10.1136/bcr-2017-220364

Abstract

A 61-year-old female with a history of advanced HIV disease and chronic hepatitis B was presented with an 8-week history of painful oral ulcers. She appeared systemically well but examination revealed multiple well-demarcated clean-based ulcers on the tongue and hard palate. Biopsy of one of the lesions showed numerous histiocytes containing intracellular yeast forms consistent with Histoplasma capsulatum var. capsulatum Fungal blood cultures subsequently grew H. capsulatum var. capsulatum, confirming a diagnosis of disseminated histoplasmosis. She was treated with intravenous amphotericin B for 2 weeks followed by a prolonged course of oral itraconazole, with which her ulcers resolved completely and have not recurred. This case exemplifies how oral ulcers may be a manifestation of an underlying systemic disease and demonstrates the utility of biopsy in establishing a diagnosis.

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