The MHC, which covers an area around 4 Mb at 6p21.3, is perhaps the most polymorphic locales in the human genome. With a high thickness of in excess of 200 qualities, the greater part of which are straightforwardly engaged with the safe reaction to self or non-self antigens, MHC qualities have for quite some time been related with a wide scope of complex human illnesses, including immune system or incendiary sicknesses and malignancy. Rheumatoid joint inflammation (RA) is a fundamental immune system illness; ongoing examinations in enormous genome-wide affiliation contemplates utilizing single-nucleotide polymorphisms have affirmed the relationship of exemplary HLA qualities and non-exemplary HLA qualities with RA in numerous populations1,2. Notwithstanding, as a result of the heterogeneity among ethnic gatherings and clinical subtypes, the significant RA-hazard allele in MHC is very extraordinary among various populaces. explicitly for RA patients positive for anticitrullinated protein antibodies (ACPA)5,6. A new report led target profound sequencing of the whole MHC area for ACPA-positive RA in a Han Chinese populace, and it found that rather than HLA-DRB1 alleles.

Reference link- https://www.jrheum.org/content/47/11/1597