Double minute chromosomes (DMs) are rare in hematologic malignancies. We presented the cytogenetic characteristics and clinical features of the largest single-center cohort of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients with DMs. A total of 2576 AML patients and 1642 MDS patients were investigated, and 30 patients (AML = 19; MDS = 11) who had DMs were followed up. DMs were more common in primary AML (94.7%) and MDS (90.9%). Monosomal karyotypes (MK) were also the main cytogenetic characteristics, like complex karyotypes (CK). AML with myelodysplasia-related changes (AML-MRC) and MDS-refractory anemia with excess blasts (MDS-RAEB) was common in this cohort. We conclude that DMs-positive AML and DMs-positive MDS are associated with older age, complex karyotypes, monosomal karyotypes, deletion and mutations. DMs are a type of chromothripsis, which can be observed by the karyotype analysis. and were the most commonly amplified genes in DMs. Most patients with DMs presented an extremely poor prognosis.
About The Expert
Nan Wang
Lijun Yuan
Yu Jing
Keke Fan
Hongshi Jin
Chao Lv
Lili Wang
Li Yu
References
PubMed