Advertisement

 

 

Drug delivery and tissue engineering to promote wound healing in the Immunocompromised host: Current challenges and future directions.

Drug delivery and tissue engineering to promote wound healing in the Immunocompromised host: Current challenges and future directions.
Author Information (click to view)

Tatara AM, Kontoyiannis DP, Mikos AG,


Tatara AM, Kontoyiannis DP, Mikos AG, (click to view)

Tatara AM, Kontoyiannis DP, Mikos AG,

Advertisement

Advanced drug delivery reviews 2017 12 05() pii 10.1016/j.addr.2017.12.001

Abstract

As regenerative medicine matures as a field, more promising technologies are being translated from the benchtop to the clinic. However, many of these strategies are designed with otherwise healthy hosts in mind and validated in animal models without other co-morbidities. In reality, many of the patient populations benefiting from drug delivery and tissue engineering-based devices to enhance wound healing also have significant underlying immunodeficiency. Specifically, patients suffering from diabetes, malignancy, human immunodeficiency virus, post organ transplantation, and other compromised states have significant pleotropic immune defects that affect wound healing. In this work, we review the role of different immune cells in the regenerative process, highlight the effect of several common immunocompromised states on wound healing, and discuss different drug delivery strategies for overcoming immunodeficiencies.

Submit a Comment

Your email address will not be published. Required fields are marked *

4 × 2 =

[ HIDE/SHOW ]