Mineral sunscreens with a broad range of protection have helped to treat pigmentary diseases. In stand-alone research, individuals with mild to moderate wrinkles and hyperpigmentation showed improvement after using a vitamin C moisturizer (VCM) containing 30% tetrahexyldecyl (THD) ascorbate. For individuals who are worried about their hyperpigmented and photodamaged face skin, a dual regimen therapy, including a 100% mineral TMS and a VCM, may provide further advantages.

For CPD production, 8-OHdG content, and H2A.X phosphorylation (n = 3), MatTek EpiDerm tissues were topically treated with 100% mineral TMS, exposed to UVB (300 mJ/cm2) 24 hours after treatment, and then incubated for an additional 24 hours. To determine the effectiveness and tolerability of a skincare regimen containing VCM and 100% mineral TMS over the course of 12 weeks, 36 female subjects (aged 35 to 60) with moderate to severe facial hyperpigmentation and moderate global face photodamage were enrolled in a multicenter, open-label study. At the start of the study, weeks 4, 8, and 12 involved clinical grading using a modified Griffith 10-point scale for hyperpigmentation, total photodamage, and skin tone evenness.

The 100% mineral TMS reduced CPD production and repaired UVB-induced DNA damage by 85% (P<.05). In patients at 3 study locations, the combination of VCM with 100% mineral TMS reduced face skin photodamage and hyperpigmentation as compared to baseline (P<.05.)

The dual regimen consisting of 100% mineral TMS combined with the VCM was highly successful and comfortable in treating hyperpigmented and photodamaged skin, according to in vitro and in vivo data.

Reference: jaad.org/article/S0190-9622(22)01116-1/fulltext