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Dynamic re-immunization of off-treatment childhood cancer survivors: An implementation feasibility study.

Dynamic re-immunization of off-treatment childhood cancer survivors: An implementation feasibility study.
Author Information (click to view)

Han JH, Harmoney KM, Dokmeci E, Torrez J, Chavez CM, Cordova de Ortega L, Kuttesch JF, Muller M, Winter SS,


Han JH, Harmoney KM, Dokmeci E, Torrez J, Chavez CM, Cordova de Ortega L, Kuttesch JF, Muller M, Winter SS, (click to view)

Han JH, Harmoney KM, Dokmeci E, Torrez J, Chavez CM, Cordova de Ortega L, Kuttesch JF, Muller M, Winter SS,

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PloS one 2018 02 0113(2) e0191804 doi 10.1371/journal.pone.0191804
Abstract

There are no universally approved re-vaccination guidelines for non-transplant pediatric cancer survivors. We hypothesized that by utilizing a response-based re-vaccination schedule, we could tailor vaccine schedules in off-treatment cancer survivors. Pre-vaccination antibody levels were obtained in 7 patients at an average of 20 days after the end of treatment date. In those without protective antibody levels, we administered vaccines 3 months after completion of treatment. Revaccinating patients 3 months after the end of treatment date resulted in protective antibody levels for most vaccines. We showed, on a preliminary basis, that vaccinating non-transplanted pediatric cancer survivors can be dynamically implemented in children with recovering immune function.

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