Advertisement

 

 

Dynamics of lentiviral infection in vivo in the absence of adaptive immune responses.

Dynamics of lentiviral infection in vivo in the absence of adaptive immune responses.
Author Information (click to view)

Schwartz EJ, Vaidya NK, Dorman KS, Carpenter S, Mealey RH,


Schwartz EJ, Vaidya NK, Dorman KS, Carpenter S, Mealey RH, (click to view)

Schwartz EJ, Vaidya NK, Dorman KS, Carpenter S, Mealey RH,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Virology 2017 10 19513() 108-113 pii 10.1016/j.virol.2017.09.023

Abstract

Understanding the dynamics of acute viral infection is crucial for developing strategies to prevent and control infection. In this study, lentiviral dynamics in a host without adaptive immunity were examined in order to determine kinetic parameters of infection and quantify the effect of neutralizing antibodies in preventing infection, using mathematical modeling of data from equine infectious anemia virus (EIAV) infection of horses with severe combined immunodeficiency (SCID). Estimated parameters were used to calculate the basic reproductive number and virus doubling time and found that the rate that antibodies neutralized virus was ~18 times greater than the virus clearance rate. These results establish EIAV replication kinetics in SCID horses and the minimal efficacy of antibodies that blocked infection. Furthermore, they indicate that EIAV is at most mildly cytopathic. This study advances our understanding of EIAV infection and may have important implications for the control of other viral infections, including HIV.

Submit a Comment

Your email address will not be published. Required fields are marked *

6 − 5 =

[ HIDE/SHOW ]