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Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection.

Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection.
Author Information (click to view)

Foster C, Pace M, Kaye S, Hopkins E, Jones M, Robinson N, Mant C, Cason J, Fidler S, Frater J, ,


Foster C, Pace M, Kaye S, Hopkins E, Jones M, Robinson N, Mant C, Cason J, Fidler S, Frater J, , (click to view)

Foster C, Pace M, Kaye S, Hopkins E, Jones M, Robinson N, Mant C, Cason J, Fidler S, Frater J, ,

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AIDS (London, England) 31(13) 1847-1851 doi 10.1097/QAD.0000000000001565

Abstract

: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

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