The course of polycystic liver disease is unknown. For a study, researchers sought to examine the relationships between polycystic liver disease progression and other disease progression characteristics, as well as to categorize liver progression based on patient age, height-adjusted liver cystic volume, and height-adjusted liver volume. Prospective longitudinal magnetic resonance imaging from 670 patients with early autosomal dominant polycystic kidney disease was analyzed for height-adjusted liver cystic volume and height-adjusted liver volume over a 14-year period. The longitudinal study comprised 245 patients with baseline hepatic cyst volumes greater than 50 mL. Linear mixed models were fitted using log-transformed height-adjusted liver cystic volume and height-adjusted liver volume to estimate the mean yearly rate of change for each outcome. The researchers looked at the relationship between sex, BMI, genotype, baseline height-adjusted total kidney capacity, and Mayo imaging class. They estimated height-adjusted liver cystic volume ranges for each age group and classified them into 5 groups based on the yearly percentage increase in height-adjusted liver cystic volume.

The mean annual growth rate of height-adjusted liver cystic volume was 12% (95% CI, 11.1% to 13.1% ; P<0.001), whereas it was 2% (95% CI, 1.9% to 2.6% ; P<0.001). Women had a greater baseline height-adjusted liver cystic volume than males, but men had a 2% faster growth rate (95% CI, 0.4% to 4.5%; P=0.02). While the height-adjusted liver cystic volume development rate in women reduced after menopause, no drop was detected in males of any age. The increased rate of height-adjusted liver cystic volume or height-adjusted liver volume was not linked with body mass index, genotype, or baseline height-adjusted total kidney volume. Patients were divided into f5 groups based on their height-adjusted liver cystic volume growth rate (number of women and men in each group): A (24, six); B (44, 13); C (43, 48); D (28, 17); and E (24, six) (13, nine). Height-adjusted liver cystic volume demonstrated higher separations in volumetric development of the polycystic liver disease than height-adjusted liver volume.

Reference:cjasn.asnjournals.org/content/early/2022/02/25/CJN.08660621