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Early-life sensitization to hen’s egg predicts asthma and rhinoconjunctivitis at 14 years of age.

Early-life sensitization to hen’s egg predicts asthma and rhinoconjunctivitis at 14 years of age.
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Christiansen ES, Kjaer HF, Eller E, Bindslev-Jensen C, Høst A, Mortz CG, Halken S,


Christiansen ES, Kjaer HF, Eller E, Bindslev-Jensen C, Høst A, Mortz CG, Halken S, (click to view)

Christiansen ES, Kjaer HF, Eller E, Bindslev-Jensen C, Høst A, Mortz CG, Halken S,

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Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2017 10 05() doi 10.1111/pai.12815
Abstract
BACKGROUND
Sensitization to both inhalant and food allergens has been shown to be risk factors for development of asthma and rhinoconjunctivitis (RC). However, few studies have addressed the role of transient or persistent IgE sensitization to specific allergens in early life for later development of allergic diseases. The aim of this study was to explore the association between transient and persistent sensitization in early-life and the development of asthma and RC at 6 and 14 years.

METHODS
The DARC cohort is a prospective non-interventional birth cohort study comprising 562 children. For the purpose of this study, we examined a subgroup of the original cohort with specific IgE measured at, at least 3 of 4 follow-ups between 3 and 18 months of age (n=366). Multiple logistic regression models were used to investigate the association between transient and persistent early-life sensitization to groups of and to individual allergens and asthma and RC at 6 and 14 years compared to a reference group with no sensitization.

RESULTS
Both transient and persistent early-life sensitization to cow’s milk or hen’s egg proteins were associated with asthma (aOR 3.99(1.41-11.32) and 5.95(1.78-19.92)) and RC (aOR 2.94(1.19-7.28) and 6.18(1.86-20.53)) at 14 years, this association being driven mainly by sensitization to hen’s egg. Transient early-life sensitization to HDM had increased risk of asthma (aOR 3.80(1.17-12.41)) at 14 years.

CONCLUSIONS
Early transient and persistent IgE sensitization to hen’s egg was associated with asthma and RC at 14 years. Furthermore, sensitization to HDM was associated with asthma at 14 years. This article is protected by copyright. All rights reserved.

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