Adults undergoing LTA after implementation of the safety net policy and were subsequently listed for KT between 60 and 365 days after liver transplantation contained in UNOS data were examined. Outcomes of interest were receipt of a kidney transplant and post liver transplant survival. Safety net patients were compared to LTA recipients not subsequently listed for KT as well as to patients listed for simultaneous liver kidney transplant (SLK) yet underwent LTA and were not subsequently listed for KT.
There were 100 patients listed for safety net KT versus 9458 patients undergoing LTA without subsequent KT listing. The cumulative incidence of KT following listing was 32.5% at 180 days. The safety net patients had similar 1-year unadjusted patient survival (96.4% vs. 93.4%; p=0.234) but superior adjusted survival (HR 0.1330.3570.960; p=0.041) versus LTA recipients not subsequently listed for KT. Safety net patients had superior 1-year unadjusted (96.4% vs. 75.0%; p<0.001) and adjusted (HR 0.0390.1260.406 ;p<0.001) survival versus SLK listed patients undergoing LTA without subsequent KT listing.
The safety net appears provide rapid access to KT with good early survival for those able to take advantage of it. Survival of patients unable to qualify for KT listing after LTA needs to be better understood prior to further limitation of SLK, however.
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.