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Early post-treatment risk stratification of differentiated thyroid cancer: comparison of three high-sensitive Tg assays.

Early post-treatment risk stratification of differentiated thyroid cancer: comparison of three high-sensitive Tg assays.
Author Information (click to view)

Giovanella L, Imperiali M, Verburg FA, Trimboli P,


Giovanella L, Imperiali M, Verburg FA, Trimboli P, (click to view)

Giovanella L, Imperiali M, Verburg FA, Trimboli P,

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European journal of endocrinology 178(1) 77-84 doi 10.1530/EJE-17-0663

Abstract
OBJECTIVE
To assess the diagnostic performance of three high-sensitive assays in a cohort of TgAb-negative and TgAb-positive differentiated thyroid cancer (DTC) patients.

DESIGN
Retrospective study on prospectively selected DTC patients.

METHODS
Serum samples from 154 DTC patients were obtained 6-12 months after radioiodine ablation and tested by Beckman, Roche, BRAHMS Tg and TgAb assays, respectively. Receiver operating characteristics curves for Tg were plotted using outcome over time as benchmark and assay-specific Tg thresholds were obtained for TgAb-negative and TgAb-positive patients.

RESULTS
The frequency of positive TgAb was 21, 20 and 20% for Beckman, Roche and BRAHMS, respectively. In TgAb-negative patients, clinical sensitivities and specificities of 100% and 85-95%, respectively, were observed across all assays. In TgAb-positive patients, clinical sensitivities and specificities of 80-100% and 92-96%, respectively, were observed using lower thresholds than in patients without TgAb.

CONCLUSIONS
Adopting appropriate thresholds, lower than those for TgAb-negative patients, is possible to reliably follow TgAb-positive patients using highly sensitive Tg assays.

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