AM is traditional Chinese medicine, has been used to treat allergic diseases, but treating AR remains unclear.
This study aimed to look at the anti-inflammatory effect of AM on AR and the mechanism of anti-allergy. The mouse model of AR was induced by ovalbumin. We explored the serum immunoglobulin E, interleukin-4, IL-5, IL-13, interferon-γ. The proportion of CD4+ CD25+ Foxp3+ T cells in the spleen and nasal lymphoid tissue were analyzed. The mRNA levels of nuclear factor-kappa B p65 and inhibitory kappa B alpha (IκBα), as well as NF-κB p65 DNA binding activity, were tested. We also measured the protein levels of NF-κB p65 and p-NF-κB p65 in the nasal mucosa.
AM could reduce the number of eosinophils in the nasal mucosa and decrease inflammatory cells’ levels in nasal lavage fluid. The relative mRNA of IL-4, IL-5, and IL-13 was being reduced by AM. However, AM had no significant effect on the mRNA of IκBα. Above all, AM could reduce the p-NF-κB p65 protein expression of the nasal mucosa.
The study concluded that AM could reduce the secretion of inflammatory cytokines by increasing the level of CD4+ CD25+ Foxp3+ T cells and inhibiting the activation of the NF-κB.
Reference: https://journals.sagepub.com/doi/full/10.1177/1945892419839259
