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Effect of Neoadjuvant Chemoradiotherapy on Lymph Node Micrometastases in Thoracic Esophageal Cancer.

Effect of Neoadjuvant Chemoradiotherapy on Lymph Node Micrometastases in Thoracic Esophageal Cancer.
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Yanagi M, Sasaki K, Uchikado Y, Omoto I, Arigami T, Kurahara H, Uenosono Y, Sakoda M, Maemura K, Natsugoe S,


Yanagi M, Sasaki K, Uchikado Y, Omoto I, Arigami T, Kurahara H, Uenosono Y, Sakoda M, Maemura K, Natsugoe S, (click to view)

Yanagi M, Sasaki K, Uchikado Y, Omoto I, Arigami T, Kurahara H, Uenosono Y, Sakoda M, Maemura K, Natsugoe S,

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Anticancer research 38(2) 893-900

Abstract
AIM
The purpose of this study was to clarify the effect of neoadjuvant chemoradiotherapy (nCRT) on lymph node micrometastasis (LNM) in esophageal squamous cell carcinoma (ESCC).

PATIENTS AND METHODS
The therapeutic efficacy of nCRT was analyzed in 41 ESCC patients randomized to the Surgery group (n=21) and the nCRT group (n=20). Lymph node specimens from patients were classified into two categories, micrometastasis (MM) and tumor cell microinvolvement (MI), after immunohistochemical evaluation.

RESULTS
The incidence rates of patients presenting MM with or without MI or MI alone in the Surgery group were significantly higher than those in the nCRT group. The 10-year survival rate of 15 patients with simultaneous histological metastasis (HM) and LNM was significantly lower than that in the 26 patients without LNM. Within the nCRT group, the 10-year survival rates of patients with versus those without HM were not significantly different; however, the 10-year survival rate of the 5 patients with simultaneous HM and LNM was significantly lower than that of the 15 patients without LNM.

CONCLUSION
ESCC patients with LNM may benefit from nCRT, and evaluation of the simultaneous presence of HM and LNM may facilitate accurate prediction of survival in ESCC patients.

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