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Effects of alliin on LPS-induced acute lung injury by activating PPARγ.

Effects of alliin on LPS-induced acute lung injury by activating PPARγ.
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Wang YL, Guo XY, He W, Chen RJ, Zhuang R,


Wang YL, Guo XY, He W, Chen RJ, Zhuang R, (click to view)

Wang YL, Guo XY, He W, Chen RJ, Zhuang R,

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Microbial pathogenesis 2017 07 12() pii S0882-4010(17)30415-1
Abstract

Alliin is a garlic organosulfur compound that possesses various pharmacological properties. In the present study, the protective effects and molecular mechanism of alliin on Lipopolysaccharides (LPS)-induced acute lung injury (ALI) were analyzed. LPS-induced ALI was induced in BALB/c mice by intranasal instillation of LPS. Alliin was administered intraperitoneally to mice 1 h after LPS treatment. The results showed that alliin markedly inhibited lung myeloperoxidase (MPO) activity and wet/dry (W/D) ratio induced by LPS. Alliin also inhibited TNF-α and IL-1β in the bronchoalveolar lavage fluid (BALF) induced by LPS. Furthermore, LPS-induced lung pathological injury was attenuated by treatment of alliin. LPS-induced NF-κB activation was significantly inhibited by alliin. In addition, the expression of peroxisome proliferator-activated receptor γ (PPARγ) was up-regulated by treatment of alliin. Taken together, these results suggested that alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response. Alliin might be used as an anti-inflammatory agent in the treatment of ALI.

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