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Effects of Maraviroc versus Efavirenz in Combination with Zidovudine-Lamivudine on the CD4/CD8 Ratio in Treatment-Naive HIV-Infected Individuals.

Effects of Maraviroc versus Efavirenz in Combination with Zidovudine-Lamivudine on the CD4/CD8 Ratio in Treatment-Naive HIV-Infected Individuals.
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Serrano-Villar S, Caruana G, Zlotnik A, Pérez-Molina JA, Moreno S,


Serrano-Villar S, Caruana G, Zlotnik A, Pérez-Molina JA, Moreno S, (click to view)

Serrano-Villar S, Caruana G, Zlotnik A, Pérez-Molina JA, Moreno S,

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Antimicrobial agents and chemotherapy 2017 11 2261(12) pii 10.1128/AAC.01763-17

Abstract

A low CD4/CD8 ratio during treated HIV infection reflects heightened immune activation and predicts death. The effects of different antiretroviral therapy regimens on CD4/CD8 ratio recovery remains unclear. We performed a post hoc analysis of the MERIT study, a randomized, double-blind trial of maraviroc versus efavirenz in combination with zidovudine-lamivudine in treatment-naive HIV-infected individuals. We found higher rates of CD4/CD8 ratio normalization with efavirenz, which was driven by a greater CD8(+) T-cell decline.

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