Anemia is an inherent complication of older individuals with end-stage renal disease (ESRD) that is associated with inflammation which in turn is an important factor in the activation of hepcidin that contributes to the decrease in serum iron. Athough resistance training (RT) seems to reduce inflammation in ESRD, its influence on hepcidin and iron availability in hemodialysis patients is unclear. Therefore, the aim of this study was to exemine the effects of RT in on inflammatory profile, hepcidin, and iron status in older individuals with ESRD. End-stage renal disease patients (N: 157, age: 66.8 ± 3.6; body mass: 73 ± 15 body mass index:27 ± 3), were assigned to control (CTL n: 76) and exercise groups (RT n: 81). RT consisted of 24 weeks/3 days per week of a moderate intensity. There was an increase in the bioavailability of iron (ΔRT: 22.2; ΔCTL: -1 μg/dL, p < 0.0001), a decrease in hepcidin levels (ΔRT: -7.9; ΔCTL: 0.2 ng/mL, p < 0.0001),and an improvement of the inflammatory profile. These novel findings show that RT is a potential coadjuvant to reduce iron deficiency by decreasing the levels of hepcidin and pro-inflammatory markers in older patients undergoing hemodialysis.Copyright © 2020. Published by Elsevier Inc.
About The Expert
Sting Ray Gouveia Moura
Hugo Luca Corrêa
Rodrigo Vanerson Passos Neves
Cláudio Avelino Rodrigues Santos
Luiz Sinésio Silva Neto
Victor Lopes Silva
Michel Kendy Souza
Lysleine Alves Deus
Andrea Lucena Reis
Herbert Gustavo Simões
Fabiani Lage Rodrigues Beal
Milton Rocha Moraes
James W Navalta
Jonato Prestes
André Bonadias Gadelha
Thiago Dos Santos Rosa
References
PubMed