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Efficacy and Safety of Combination Therapy Consisting of Angiotensin II Type 1 Receptor Blocker, Calcium Channel Blocker and Hydrochlorothiazide in Patients With Hypertension.

Efficacy and Safety of Combination Therapy Consisting of Angiotensin II Type 1 Receptor Blocker, Calcium Channel Blocker and Hydrochlorothiazide in Patients With Hypertension.
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Shiga Y, Miura SI, Motozato K, Yoshimine Y, Norimatsu K, Arimura T, Koyoshi R, Morii J, Kuwano T, Inoue K, Shirotani T, Fujisawa K, Matsunaga E, Saku K,


Shiga Y, Miura SI, Motozato K, Yoshimine Y, Norimatsu K, Arimura T, Koyoshi R, Morii J, Kuwano T, Inoue K, Shirotani T, Fujisawa K, Matsunaga E, Saku K, (click to view)

Shiga Y, Miura SI, Motozato K, Yoshimine Y, Norimatsu K, Arimura T, Koyoshi R, Morii J, Kuwano T, Inoue K, Shirotani T, Fujisawa K, Matsunaga E, Saku K,

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Journal of clinical medicine research 2016 12 319(2) 98-103 doi 10.14740/jocmr2838w
Abstract
BACKGROUND
Many patients continue to have high blood pressure (BP) even after treatment with high-dose (H)-angiotensin II type 1 receptor blocker (ARB)/calcium channel blocker (CCB) or middle-dose (M)-ARB/CCB/hydrochlorothiazide (HCTZ).

METHODS
Thirty-two hypertensive patients who had the use of H-ARB/CCB or M-ARB/CCB/HCTZ were enrolled in this study. We applied a changeover with a switch to H-ARB (telmisartan 80 mg/day)/CCB (amlodipine 5 mg/day or nifedipine CR 40 mg/day)/HCTZ (12.5 mg/day).

RESULTS
Systolic BP (SBP) and diastolic BP (DBP) were significantly decreased in all patients and in the H-ARB/CCB and M-ARB/CCB/HCTZ groups after 3 months. Percentage (%) of patients who reached the target BP after 3 months (72%) in all patients was significantly higher than that at 0 months (19%). There were no serious adverse effects in any of the patients.

CONCLUSIONS
Combination therapy with H-ARB/CCB/HCTZ was associated with a significant reduction of BP.

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