Although polyethylene glycol (PEG) is the most efficient colon cleanser, volume-related side effects are prevalent. Although split-dose PEG is used in adults, no paediatric studies have been conducted to compare split-dose PEG to single-dose PEG. The purpose of this study was to compare the effectiveness and tolerability of split-dose PEG vs single-dose PEG for bowel preparation in children. Children were randomly assigned to either a single-dose or a split-dose PEG. The single-dose group got 4000 mL/1.73 m2 PEG solution the day before colonoscopy, while the split-dose group received half the dosage the day before and the other half on the day of colonoscopy. The effectiveness of bowel preparation was evaluated using the Aronchik scale by an endoscopist who was unaware of the kind of preparation. The experiment was registered with India’s Clinical Trials Registry. The trial was completed by 179 of the 220 randomised youngsters. The study population’s average age was 11.51 years. With virtually complete inter-observer agreement, the effectiveness of bowel preparation was improved with split-dose. The split-dose group experienced considerably less nausea, vomiting, and sleep disruption than the single-dose group. Split-dose individuals were able to consume PEG solutions more quickly. Total sleep length and undisturbed sleep duration were similarly longer in the split-dose group than in the single-dose group.

Split-dose PEG is more effective than single-dose PEG for bowel preparation in children, with greater tolerability and sleep quality.