This observation Preclinical proof shows that the endocannabinoid framework is engaged with neural reactions to remunerate. This examination meant to explore the relationship between basal serum groupings of the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) with cerebrum practical prize handling. Furthermore, a character proportion of remuneration reliance was gotten. Mind utilitarian information was acquired of 30 right-gave grown-ups by directing fMRI at 3 Tesla utilizing a prize worldview. Prize reliance was acquired utilizing the subscale reward reliance of the Tridimensional Personality Questionnaire (TPQ). Basal convergences of AEA and 2-AG were resolved in serum. Dissecting the fMRI information, for AEA and 2-AG ANCOVAs were determined utilizing a full factorial model, with condition (reward > control, loss > control) and fixations for AEA and 2-AG as components. Relapse investigations were directed for AEA and 2-AG on TPQ-RD scores. An entire cerebrum investigation indicated a huge cooperation impact of AEA focus by condition (positive versus negative) inside the putamen (x = 26, y = 16, z = −8, F13.51, TFCE(1, 54) = 771.68, k = 70, PFWE = 0.044) coming about because of a positive relationship of basal AEA fixations and putamen action to compensating improvements, while this affiliation was missing in the misfortune condition. AEA fixations were fundamentally contrarily related with TPQ reward reliance scores (rspearman = −0.56, P = 0.001). These outcomes show that flowing AEA may regulate mind enactment during remuneration criticism and that the character measure reward reliance is corresponded with AEA fixations in solid human volunteers. Therefore it sums up that Future exploration is expected to additionally describe the idea of the lipids’ effect on remuneration preparation, the effect on remuneration expectation and result, and on weakness for mental problems.