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Engineering mammalian designer cells for the treatment of metabolic diseases.

Engineering mammalian designer cells for the treatment of metabolic diseases.
Author Information (click to view)

Wang Y, Wang M, Dong K, Ye H,


Wang Y, Wang M, Dong K, Ye H, (click to view)

Wang Y, Wang M, Dong K, Ye H,

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Biotechnology journal 2017 11 16() doi 10.1002/biot.201700160
Abstract

Synthetic biology applies engineering principles to biological systems and has significantly advanced the design of synthetic gene circuits that can reprogram cell activities to perform new functions. The ability to engineer mammalian designer cells with robust therapeutic behaviors has brought new opportunities for treating metabolic diseases. In this review, we highlight the most recent advances in the development of synthetic designer cells uploaded with open-loop gene circuits or closed-loop gene circuits for the treatment of metabolic disorders including diabetes, hypertension, hyperuricemia and obesity, and discuss the current technologies and future perspectives in applying these designer cells for clinical applications. In the future, more and more rationally designed cells will be constructed and revolutionized to treat a number of metabolic disorders in an intelligent manner.

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