Advertisement

 

 

Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training.

Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training.
Author Information (click to view)

Fyfe JJ, Bishop DJ, Bartlett JD, Hanson ED, Anderson MJ, Garnham AP, Stepto NK,


Fyfe JJ, Bishop DJ, Bartlett JD, Hanson ED, Anderson MJ, Garnham AP, Stepto NK, (click to view)

Fyfe JJ, Bishop DJ, Bartlett JD, Hanson ED, Anderson MJ, Garnham AP, Stepto NK,

Advertisement

Scientific reports 2018 01 128(1) 560 doi 10.1038/s41598-017-18887-6
Abstract

Combining endurance training with resistance training (RT) may attenuate skeletal muscle hypertrophic adaptation versus RT alone; however, the underlying mechanisms are unclear. We investigated changes in markers of ribosome biogenesis, a process linked with skeletal muscle hypertrophy, following concurrent training versus RT alone. Twenty-three males underwent eight weeks of RT, either performed alone (RT group, n = 8), or combined with either high-intensity interval training (HIT+RT group, n = 8), or moderate-intensity continuous training (MICT+RT group, n = 7). Muscle samples (vastus lateralis) were obtained before training, and immediately before, 1 h and 3 h after the final training session. Training-induced changes in basal expression of the 45S ribosomal RNA (rRNA) precursor (45S pre-rRNA), and 5.8S and 28S mature rRNAs, were greater with concurrent training versus RT. However, during the final training session, RT further increased both mTORC1 (p70S6K1 and rps6 phosphorylation) and 45S pre-rRNA transcription-related signalling (TIF-1A and UBF phosphorylation) versus concurrent training. These data suggest that when performed in a training-accustomed state, RT induces further increases mTORC1 and ribosome biogenesis-related signalling in human skeletal muscle versus concurrent training; however, changes in ribosome biogenesis markers were more favourable following a period of short-term concurrent training versus RT performed alone.

Submit a Comment

Your email address will not be published. Required fields are marked *

eleven + 5 =

[ HIDE/SHOW ]