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Enteral nutrition is associated with a decreased risk of surgical intervention in Crohn’s disease patients with spontaneous intra-abdominal abscess.

Enteral nutrition is associated with a decreased risk of surgical intervention in Crohn’s disease patients with spontaneous intra-abdominal abscess.
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Zheng XB, Peng X, Xie XY, Lian L, Wu XR, Hu JC, He XW, Ke J, Chen YF, Zhi M, Wu XJ, He XS, Lan P,


Zheng XB, Peng X, Xie XY, Lian L, Wu XR, Hu JC, He XW, Ke J, Chen YF, Zhi M, Wu XJ, He XS, Lan P, (click to view)

Zheng XB, Peng X, Xie XY, Lian L, Wu XR, Hu JC, He XW, Ke J, Chen YF, Zhi M, Wu XJ, He XS, Lan P,

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Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 2017 10 05109() doi 10.17235/reed.2017.5116/2017
Abstract
BACKGROUND
The impact of enteral nutrition (EN) on surgical risk in Crohn’s disease (CD) patients suffering from spontaneous intra-abdominal abscess (IAA) was evaluated.

METHODS
CD patients diagnosed with spontaneous IAA from 2008 to 2015 were included in the study. The impact of EN on surgical risk was evaluated using both univariate and multivariate analyses.

RESULTS
A total of 87 patients were enrolled, 66 (75.9%) were male. The mean age at the development of an abscess was 30.2 ± 10.1 years and the median duration of illness from CD diagnosis until the development of an abscess was three (2-6) years. After a median follow-up of 1.9 (1.1-2.9) years, surgical intervention was performed in 42 patients (48.3%). Patients treated with EN were less likely to require surgical intervention (26.1% vs 56.3%, p = 0.01). Multivariate analysis showed that EN was an independent protective factor for the risk of surgery with a hazard ratio of 0.27 (95% confidence interval: 0.11-0.65, p = 0.004) after adjusting for abdominal pain, history of abdominal surgery, concomitant intestinal stenosis and prior use of antibiotics within three months.

CONCLUSIONS
Surgical intervention is common for CD patients with IAA. Appropriate application of EN may help obviate the need for surgical treatment.

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