Esophageal squamous cell papilloma (ESP) is recognised rarely. Usually it is the finding of diagnostic esophagogastroduodenoscopy (EGD). It is considered as asymptomatic benign lesion, in most cases solitary. Larger papilloma and papillomatous lesions are extremely rare and can cause dysphagia, odynophagia, or bleeding. Squamous cell papilloma of esophagus is the lesion of unknown potential for malignant transformation, which currently has no guidelines for endoscopic surveillance. The aim of the study was to present the patient diagnosed with squamous cell papillomas of oesophagus, method of treatment and endoscopic surveillance.
The 65-year-old woman was referred for investigation of epigastric pain and heartburn. The EGG was performed. The normal esophageal mucosa was found with presence of several papillomatous structures from 3 to 8 mm in size within 25-30 cm of incisors line. One 3 mm ESP was completely removed. From the biggest lesion biopsy was obtained. Histopatological examination revealed squamous cell papilloma of oesophagus. However no HPV was detcted. Three months later patient underwent endoscopic resection of ESPs. Two, 8 mm lesions were removed completely by diathermic snare and five 3 mm lesions were removed by biopsy forceps. Histopatological examination of the resected specimen was the same as the previous examination and reveled squamous cell papilloma without HPV presence. After 6 months, no recurrence of papillomas was found in the control EGD, however, it was decided to conduct endoscopic surveillance and perform follow-up EGD in a year’s time. Radical removal of squamous cell papillomas of the esophagus was performed using endoscopic resection. After 6 months recurrence of papillomas was not confirmed.
Esophageal squamous papillomas are efficiently removed by endoscopic resection. Esophagogastroduodenoscopy may be used as a method of endoscopic surveillance.

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