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Establishment of a new initial dose plan for vancomycin using the generalized linear mixed model.

Establishment of a new initial dose plan for vancomycin using the generalized linear mixed model.
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Kourogi Y, Ogata K, Takamura N, Tokunaga J, Setoguchi N, Kai M, Tanaka E, Chiyotanda S,


Kourogi Y, Ogata K, Takamura N, Tokunaga J, Setoguchi N, Kai M, Tanaka E, Chiyotanda S, (click to view)

Kourogi Y, Ogata K, Takamura N, Tokunaga J, Setoguchi N, Kai M, Tanaka E, Chiyotanda S,

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Theoretical biology & medical modelling 2017 04 0814(1) 8 doi 10.1186/s12976-017-0054-9
Abstract
BACKGROUND
When administering vancomycin hydrochloride (VCM), the initial dose is adjusted to ensure that the steady-state trough value (Css-trough) remains within the effective concentration range. However, the Css-trough (population mean method predicted value [PMMPV]) calculated using the population mean method (PMM) often deviate from the effective concentration range. In this study, we used the generalized linear mixed model (GLMM) for initial dose planning to create a model that accurately predicts Css-trough, and subsequently assessed its prediction accuracy.

METHODS
The study included 46 subjects whose trough values were measured after receiving VCM. We calculated the Css-trough (Bayesian estimate predicted value [BEPV]) from the Bayesian estimates of trough values. Using the patients’ medical data, we created models that predict the BEPV and selected the model with minimum information criterion (GLMM best model). We then calculated the Css-trough (GLMMPV) from the GLMM best model and compared the BEPV correlation with GLMMPV and with PMMPV.

RESULTS
The GLMM best model was {[0.977 + (males: 0.029 or females: -0.081)] × PMMPV + 0.101 × BUN/adjusted SCr – 12.899 × SCr adjusted amount}. The coefficients of determination for BEPV/GLMMPV and BEPV/PMMPV were 0.623 and 0.513, respectively.

CONCLUSION
We demonstrated that the GLMM best model was more accurate in predicting the Css-trough than the PMM.

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