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Estimating burden of influenza-associated influenza-like illness and severe acute respiratory infection at public health care facilities in Romania during the 2011/12-2015/16 influenza seasons.

Estimating burden of influenza-associated influenza-like illness and severe acute respiratory infection at public health care facilities in Romania during the 2011/12-2015/16 influenza seasons.
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Gefenaite G, Pistol A, Popescu R, Popovici O, Ciurea D, Dolk C, Jit M, Gross D,


Gefenaite G, Pistol A, Popescu R, Popovici O, Ciurea D, Dolk C, Jit M, Gross D, (click to view)

Gefenaite G, Pistol A, Popescu R, Popovici O, Ciurea D, Dolk C, Jit M, Gross D,

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Influenza and other respiratory viruses 2017 11 16() doi 10.1111/irv.12525
Abstract
BACKGROUND
Influenza is responsible for substantial morbidity and mortality, but there is limited information on reliable disease burden estimates, especially from middle-income countries in the WHO European Region.

OBJECTIVES
To estimate the incidence of medically attended influenza-associated influenza-like illness (ILI) and hospitalizations due to severe acute respiratory infection (SARI) presenting to public health care facilities in Romania.

PATIENTS/METHODS
Sentinel influenza surveillance data for ILI and SARI from 2011/12-2015/16, including virological data, was used to estimate influenza-associated ILI and SARI incidence/100000 and their 95% confidence intervals (95% CI).

RESULTS
The overall annual incidence of ILI and influenza-associated ILI per 100.000 persons in Romania varied between 68 (95%CI 61 to 76) and 318 (95%CI 298 to 338) and between 23 (95%CI 19 to 29) and 189 (95%CI 149 to 240) respectively. The highest ILI and influenza incidence was among children 0 to 4 years old. We estimated that SARI incidence per 100.000 persons was 6 (95%CI 5 to 7) to 9 (95%CI 8 to 10), of which 2 (95%CI 1 to 2) to 3 (95%CI 2 to 4) were due to influenza. Up to 0.3% of the Romanian population were annually reported with ILI, and 0.01% was hospitalized with SARI, of which as much as one third could be explained by influenza.

CONCLUSIONS
This evaluation was the first study estimating influenza burden in Romania. We found that during each influenza season, a substantial number of persons in Romania suffer from influenza related ILI or are hospitalized due to influenza-associated SARI. This article is protected by copyright. All rights reserved.

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