Advertisement

 

 

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.
Author Information (click to view)

Bartha I, McLaren PJ, Brumme C, Harrigan R, Telenti A, Fellay J,


Bartha I, McLaren PJ, Brumme C, Harrigan R, Telenti A, Fellay J, (click to view)

Bartha I, McLaren PJ, Brumme C, Harrigan R, Telenti A, Fellay J,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

PLoS computational biology 2017 02 0913(2) e1005339 doi 10.1371/journal.pcbi.1005339

Abstract

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.

Submit a Comment

Your email address will not be published. Required fields are marked *

eleven + six =

[ HIDE/SHOW ]