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ETV6-NTRK3 and STRN-ALK kinases fusions are recurrent events in papillary thyroid cancer of adult population.

ETV6-NTRK3 and STRN-ALK kinases fusions are recurrent events in papillary thyroid cancer of adult population.
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Bastos AU, de Jesus AC, Cerutti JM,


Bastos AU, de Jesus AC, Cerutti JM, (click to view)

Bastos AU, de Jesus AC, Cerutti JM,

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European journal of endocrinology 2017 10 18() pii 10.1530/EJE-17-0499

Abstract
OBJECTIVE
PTC-specific analysis identified novel fusions involving RET, BRAF, NTRK1, NTRK3, AGK and ALK genes in adults and pediatric PTC. Although many novel fusions are PTC-specific event and, therefore, are ideal for diagnosis purposes, validation across additional and larger cohorts is essential for introducing these potential diagnostic or prognostic biomarkers into the clinical practice. As most of the BRAF, NTRK3 and ALK fusions were initially found in pediatric PTC or in more aggressive thyroid carcinomas, and there is a great disparity across population, in this study, we screened a large set of adult sporadic PTC cases for the most prevalent kinases fusion lately described in the TCGA.

DESIGN AND METHODS
The prevalence of the fusions was determined by RT-PCR in 71 classical PTC, 45 follicular variant of PTC (FVPTC), 19 follicular thyroid adenomas (FTA) and 22 follicular thyroid carcinomas (FTC).

RESULTS
ETV6-NTRK3 was exclusively found in FVPTC, in both encapsulated and infiltrative variants, but was not found in FTAs and FTCs. STRN-ALK was found in both classical PTC and FVPTC. No AGK-BRAF fusion was identified in this series, endorsing that AGK-BRAF is a genetic event mainly associated with pediatric PTCs.

CONCLUSIONS
The identification of kinases fusions in thyroid carcinomas helps to expand our knowledge about the landscape of oncogenic alterations in PTC. As ETV6-NTRK3 and STRN-ALK are recurrent and not identified in benign lesions, they can certainly help with diagnosis of thyroid nodules. Further analysis is needed to define if they can also be useful for prognosis and guiding therapy.

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