The following is a summary of “Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression,” published in the November 2023 issue of Infectious Disease by Jia et al.
Researchers started a retrospective study to analyze the relationship between colorectal polyps (CRP) and Helicobacter pylori (H. pylori) infection, as well as between CRP and phosphorylated ribosomal protein S6 kinase (p-S6K1) expression, and to identify potential influencing factors.
They selected 191 subjects who had undergone colonoscopy. Among them, 141 patients received a diagnosis of CRP, while the remaining 50 subjects showed no significant colorectal abnormalities. The 141 CRP patients were categorized into an H. pylori-positive group (n = 89) and an H. pylori-negative group (n = 52) based on H. pylori test results. Examining p-S6K1 expression in CRP tissue, the expression’s relationship with clinicopathological characteristics in CRP patients was analyzed. Logistic analysis was conducted to identify factors influencing the occurrence of CRP.
The results showed notable differences in pathological type, disease site, number, and size of polyps between the H. pylori-negative group and the H. pylori-positive group (P<0.001, P=0.037, P=0.042, and P=0.039). The percentage of p-S6K1 positive expression in polyp tissues surpassed that in normal and para polyp tissues (P<0.001). The p-S6K1 negative group exhibited notable disparities in the number and pathological type of polyps and the presence or absence of a pedicle compared to the p-S6K1 positive group (P=0.006, P<0.001, and P=0.012). The logistic multifactor analysis identified BMI, H. pylori infection, smoking history, ApoB, Lp(a), and p-S6K1 positive expression as risk factors for CRP development (P=0.025, P=0.020, P=0.010, P=0.005, P=0.043, and P<0.001).
They concluded that H. pylori infection and p-S6K1 expression were implicated in the development of colorectal polyps, warranting further investigation into preventive and screening measures.
Source: bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-023-08791-y
