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Expression and Clinical Correlations of Co-Stimulatory Molecules on Peripheral T Lymphocyte Subsets of Early-Stage Severe Sepsis: A Prospective Observational Study.

Expression and Clinical Correlations of Co-Stimulatory Molecules on Peripheral T Lymphocyte Subsets of Early-Stage Severe Sepsis: A Prospective Observational Study.
Author Information (click to view)

Lu Y, An L, Liu Q, Li C,


Lu Y, An L, Liu Q, Li C, (click to view)

Lu Y, An L, Liu Q, Li C,

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Shock (Augusta, Ga.) 2017 10 12() doi 10.1097/SHK.0000000000001017
Abstract
OBJECTIVE
To investigate the expression and clinical correlations of co-stimulatory molecules on peripheral T cell subsets of severe sepsis (SS) patients.

METHODS
Blood samples of patients with community-acquired pneumonia associated SS and healthy controls (HCs) were analyzed. SS patients were followed up for 28 days. Co-stimulatory molecules expression on T cell subsets was determined by flow cytometry analysis. The clinical correlations of these parameters were examined.

RESULTS
92 SS patients and 29 HCs were recruited. Higher frequency of CD28, CD27, OX40 on CD4+ T cells, OX40 on CD4+CD27-CD28- T cells and lower frequency of CD4+CD27-CD28- T cells in the SS group compared with the HC group and in the non-survived compared with the survived SS subgroup were observed. The SS group and the non-survived SS subgroup exhibited lower frequency of 4-1BB on either CD8+ or CD4+ T cells. The frequency of regulatory T cells (Tregs), OX40+ Tregs and 4-1BB+ conventional T cells (Tconvs) were higher in the SS group. The frequency of CD4+CD27+ T cells, CD4+CD28+ T cells, and OX40+ on CD4+CD27-CD28- T cells were positively correlated with the sequential organ failure assessment (SOFA) score. The frequency of CD4+CD27+ T cells and OX40+ on CD4+CD27-CD28- T cells independently predicted 28-day mortality.

CONCLUSION
Early-stage SS patients exhibited an activated T cell phenotype. Imbalanced OX40 and 4-1BB expression presented on Tregs and Tconvs may contribute to a functional imbalance of Tregs/Tconvs. The frequency of CD4+CD27+ T cells and OX40+ on CD4+CD27-CD28- T cells predicted 28-day mortality of SS.

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